Protein Details: Voltage-gated Potassium channel-interacting protein 1

Protein ID

ICDB_Pro_1299

Protein Name

Voltage-gated Potassium channel-interacting protein 1

Gene Name

Kcnip1; Kchip1

Organism

Rattus norvegicus (Rat)

Length

227 amino acids

AlphaFoldDB

AF-Q8R426-F1-model_v4.pdb

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density; inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND2/Kv4.2 currents. In vitro; modulates KCND1/Kv4.1 currents (By similarity). Increases the presence of KCND2 at the cell surface

Sequence

MGAVMGTFSSLQTKQRRPSKDIAWWYYQYQRDKIEDDLEMTMVCHRPEGLEQLEAQTNFTKRELQVLYRGFKNECPSGVVNEETFKQIYAQFFPHGDASTYAHYLFNAFDTTQTGSVKFEDFVTALSILLRGTVHEKLRWTFNLYDINKDGYINKEEMMDIVKAIYDMMGKYTYPVLKEDTPRQHVDVFFQKMDKNKDGIVTLDEFLESCQEDDNIMRSLQLFQNVM

PDB Structures

1S6C

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

146;148;150;152;157;194;196;198;205

Disease

Location

Detected in hippocampus and in the molecular layer of the dentate gyrus (at protein level). Isoform 1 and isoform 2 are predominantly expressed at equal levels in brain. Colocalizes with KCND3 in inhibitory interneurons in cortex and hippocampus and in striatal interneurons.

DOI ID

10.1006/bbrc.2001.4558; 10.1152/ajpcell.00416.2002; 10.1038/35000592; 10.1016/s0014-5793(01)02560-1; 10.1523/jneurosci.0776-04.2004; 10.1016/s0896-6273(04)00045-5

RefSeq

NP_001248318.1 [Q8R426-1]